Deep Dive MW R22

Guillain-Barre Syndrome (GBS) – Autoimmune polyneuropathy that results in widespread demylination of peripheral nerves



Typically occur 1 week after a triggering infection



Paresthesias/Neuropathic Pain -> Ascending symmetric paralysis -> Respiratory Failure



Major Diagnostic Criteria




* Progressive limb weakness in multiple limbs that is relatively symmetric



* Diminished/Absent deep tendon reflexes in affected limbs



* No alternative diagnosis



* CSF studies have false-negatives – May see albuminocytologic dissociation (Elevated protein with normal cell counts)




Treatment – IVIG and monitor respiratory status