tPA (Deep Dive R29)

tPA usage is controversial. Listen to find out why. Read more to form your own opinions.



Episode Sources:



After Re-Analysis, No Trials Show Efficacy of tPA in Acute Ischemic Stroke



Clinical Policy: Use of Intravenous Tissue Plasminogen Activator for the Management of Acute Ischemic Stroke in the Emergency Department



Why we can’t trust clinical guidelines – BMJ



Alteplase for Stroke: Money and Optimistic Claims Buttress the “Brain Attack” Campaign



Tissue Plasminogen Activator (tPA) for Acute Ischemic Stroke: Net benefits and harms unclear due to uncertainty in data – the NNT