July 9, 2026

Alzheimer’s and Gum Disease: Exploring the Role of Oral Bacteria in Brain Health | Dr. Michael Detke

Alzheimer’s and Gum Disease: Exploring the Role of Oral Bacteria in Brain Health | Dr. Michael Detke
Alzheimer’s and Gum Disease: Exploring the Role of Oral Bacteria in Brain Health | Dr. Michael Detke
Let's Talk Alzheimer's
Alzheimer’s and Gum Disease: Exploring the Role of Oral Bacteria in Brain Health | Dr. Michael Detke
Could bacteria linked to gum disease play a role in Alzheimer’s disease? Emerging science suggests that P. gingivalis, a bacterium associated with gum disease, may contribute to inflammation and brain damage linked to Alzheimer’s disease. In this episode, Dr. Michael J. Detke of Lighthouse Pharma discusses the SPRING clinical trial and the investigational oral drug LHP588, which is being studied as a potential way to reduce bacteria-related brain damage. He also shares who may qualify for the study and what participation may involve for individuals with mild to moderate Alzheimer’s and their caregivers. To learn more, watch our full conversation with Dr. Detke, part of the Zoom In on Dementia and Alzheimer’s series. https://www.brightfocus.org/resource/the-spring-trial-targeting-gum-bacteria-in-alzheimers/ Support for Let’s Talk Alzheimer’s is provided by sponsors Lilly, Biogen, Eisai, and Genentech. Let’s Talk Alzheimer’s is presented by Alzheimer’s Disease Research, a BrightFocus Foundation program. We fund exceptional research across the globe to support the development of cutting-edge treatments, risk reduction strategies, and ultimately a cure for this mind-stealing disease. Visit brightfocus.org to learn more and get involved.