Mississippi Grind is a drama about gamblers who hook up for a road trip, traveling down the Mississippi to Louisiana. Ben Mendelsohn plays Gerry, who has been down on his luck for so long, he's too far in the hole to even see the daylight of how to get up anymore. He's lost his wife, his child, his house, eventually his job, and it's getting to the point where there's really nothing left to lose, except perhaps his life, if he can't pay back all of the money he owes everyone to feed his addiction. He's been avidly listening to audiotapes to help him read other players to get a leg up in poker matches, but can't seem to stop himself from broadcasting that he's a loser. Things take a turn of a sort when a fast-talking drifter named Curtis (Reynolds) enters one of his games, and the two find a way to become fast friends, with Gerry hoping that some of Curtis's confidence and luck will continue to rub off on him as they decide to travel together to New Orleans to make a major play in a high-stakes poker tournament.