Ep. 230: “Neuronal Diversity” Featuring Dr. Paola Arlotta

Guest:

Dr. Paola Arlotta is the Golub Family Professor of Stem Cell and Regenerative Biology at Harvard University. She is interested in understanding the molecular laws that govern the birth, differentiation, and assembly of the human brain’s cerebral cortex.  She talks about using organoids to study the genetics of autism. She also discusses single-cell sequencing of brain organoids and how to make single-cell sequencing methods and data more accessible.

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The Stem Cell Science Round Up

Reactivating Neurons After Paralysis – Scientists identified a population of excitatory interneurons that are essential for the recovery of walking with epidural electrical stimulation following spinal cord injury.

Lamin A/C, Chromatin Organization, and Cardiomyopathy – Researchers uncovered divergent functions of lamin A/C in naïve pluripotent stem cells and cardiomyocytes.

HSC Colonization of the Bone Marrow – Scientists identified ligand-receptor pairs likely to be involved in fetal HSC migration and maintenance.

Rhinoceros Organoids – Researchers generated iPSCs from a Sumatran rhino, characterized them comprehensively, and differentiated them into cerebral organoids.

Photo Reference: Courtesy of Dr. Paola Arlotta

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