Episodes

What makes a great skincare formula truly effective? It’s not just what’s in it; it’s how those ingredients are delivered. In this episode of A SkinDepth Convo, Lira Clinical founders Metaxia Dalikas and Francine Kagarakis, along with Anna Kagarakis, are joined by the Lira Clinical Education Team, Tiffany Fraedrich and Alex Vetterlein, to explore the science behind EXO-tech™, Lira Clinical’s umbrella of advanced delivery technologies. From PDRN and peptides to NAD+ and growth factors, today’s ...

When new skincare technology emerges, questions naturally follow, and understanding the science is just as important as seeing the results. In this episode of A SkinDepth Convo, Lira Clinical founders Metaxia Dalikas and Francine Kagarakis speak with Dr. Aryé Elfenbein, Co-Founder of Wildtype, and Dr. Larry Weiss, Co-Founder and Managing Director of BiomeMimetics, LLC. Together, they reveal the science behind Marine Cellular Complex, also known as Wild Salmon Stem Cell Conditioned Media—the inn...

The future of regenerative skincare is here. Join Metaxia, Francine, and Anna as they pull back the curtain on the launch of REGEN Line, Lira Clinical’s groundbreaking new collection designed to support skin recovery, renewal, and long-term skin health. In this special episode, they explore the science behind two buzzworthy innovations: PDRN and Wild Salmon Stem Cell-CM, and discuss how these advanced ingredients are transforming both professional treatments and home care. From concept to clin...

In this groundbreaking episode of A SkinDepth Convo, hosts Metaxia Dalikas, Francine Kagarakis, and Anna Kagarakis are joined by the Wildtype team for an in-depth conversation on how biotechnology and regenerative science are transforming the future of skincare. Together, they explore the evolution of next-generation ingredients, from the growing interest in PDRN to Wildtype’s breakthrough innovation: Marine Cellular Complex, also known as Wild Salmon Stem Cell Conditioned Media. The discussion...

In this episode of A SkinDepth Convo, hosts Metaxia Dalikas, Francine Kagarakis, and Anna Kagarakis explore the powerful connection between internal health and skin health, revealing why true radiance starts from within. From the role of the microbiome to liver function and cellular renewal, the conversation dives into how the body’s internal systems directly influence the skin’s appearance, resilience, and overall vitality. Drawing from their deep expertise and experience as founders of Lira C...

Purely Clinical is more than an event; it’s an experience where education meets innovation and the future of skincare takes shape. Over the past year, the Lira Clinical owners traveled across the globe delivering advanced education, protocol-driven learning, and exclusive first looks at upcoming innovations, straight to the treatment room. We’re recapping standout moments from the tour stops and unpacking what attendees truly gained, from interactive sessions and protocol development to testing...

As we close the chapter of 2025 and reflect on all the things we accomplished, let's not forget the funny moments. Relive the laughs, bloopers, and real behind-the-scenes chaos that made 2025 unforgettable.

From breakthrough launches to meaningful milestones, this episode of A SkinDepth Convo reflects on a year that shaped the future of clinical aesthetics. Join us as we revisit our defining moments, celebrating innovation, education, and the community that made it all possible. We look back on 2025, on a year of growth, innovation, and momentum, while setting intentions for what’s next. Tune in for a thoughtful recap of 2025 and a celebration of how far we’ve come together.

In this episode of A SkinDepth Convo, hosts Metaxia Dalikas, Francine Kagarakis, and Anna Kagarakis dive into the beauty and complexity of treating diverse skin tones. Skincare is never one-size-fits-all, and understanding the needs of every background, heritage, and Fitzpatrick type is essential for truly inclusive care. Joined by Licensed Esthetician Gerline Jean-Louis, owner of SYNRG and a renowned practitioner specializing in higher Fitzpatrick skin types, Gerline shares her passion for edu...

Things are getting spooky at A SkinDepth Convo! Hosts Anna Kagarakis, Metaxia Dalikas, and Francine Kagarakis are joined by the rest of the fabulous founders of Lira Clinical, Brenda Cumming, and Anna Konstantin, for a Halloween special you don’t want to miss. From real-life treatment room scares to lessons learned the hard way, these skincare pros share chilling (and hilarious) stories that remind us why education, safety, and the right products are no trick; they’re the ultimate treat. So gr...

This October, in honor of Breast Cancer Awareness Month, we're sharing a deeply personal and inspiring story from Lira Clinical Co-Founder Metaxia Dalikas. As a breast cancer survivor, Metaxia opens up about her journey of courage, faith, and resilience, both in her personal battle and in her leadership of a global skincare company. In this powerful episode, Metaxia discusses her diagnosis and treatment experience, the challenges of balancing her health while running a business, and the incredi...

Join us for an exciting episode as we explore the beauty and skincare landscape down under! We're welcoming special guests from Lira Clinical's Australia and New Zealand distribution teams - Kristen Schultz and Jo-Ann Slecht - along with Lira Clinical founders Metaxia Dalikas and Francine Kagarakis, plus owner Brenda Cumming. Discover the top skin conditions affecting the Oceania region and learn about the treatments and products making a real impact for clients. We'll also take you behind the ...

On the new episode of A SkinDepth Convo, we're diving deep into our new favorite seasonal ingredient: Pumpkin! When you think of pumpkin, your mind might go straight to lattes, pies, and fall decorations. But did you know it's also a powerhouse ingredient in skincare? Packed with vitamins and minerals, pumpkin brightens, hydrates, and repairs the skin, making it a true multitasking marvel. It's more than just a seasonal craze; it's a skincare game-changer. Join our hosts Metaxia Dalikas, Franc...

In the latest episode of A SkinDepth Convo, hosts Metaxia, Francine, and Anna explore one of dermatology's most critical topics: skin cancer treatment through Mohs surgery. Did you know success rates for Mohs Surgery are over 99% for basal cell carcinoma? Joining us is Dr. Mariam Mafee MD, a board-certified dermatologist and Mohs surgeon at Rush University Medical Center (rush.edu) in Chicago. Known for her surgical expertise and compassionate patient care, Dr. Mariam Mafee discusses the intri...

Get ready for an empowering discussion about women’s health, regenerative aesthetics, and building confidence from the inside out! In this episode, hosts Metaxia Dalikas and Francine Kagarakis are joined by the incredible Dr. Chantal Lunderville, a physician trained at UCLA and UCSF and Lipgloss & Aftershave Medical + Wellness Editor, who’s redefining aging with a bold, holistic approach to esthetics and wellness. Hear from Dr. C, founder of her own esthetic practice and host of the podcast “Sp...

In the second part of Understanding Cosmetic Chemistry of A SkinDepth Convo, Metaxia and Francine are joined once again by cosmetic chemist, Dr. Gabriella Baki, to breakdown the science behind one of the most essential skincare products: sunscreen. From understanding how SPF is formulated to exploring its critical importance for ALL Fitzpatrick skin types, this conversation dives deep into the science behind shielding your skin. We’ll explore the link between melanin and SPF, clear up common my...

Get ready for Part One of a special two-part episode of A SkinDepth Convo! Part one dives into one of the most essential yet overlooked aspects of skincare science: Emulsions. Then, in part two, we’ll explore the chemistry behind sunscreen and SPFs. Joining Metaxia and Francine is a true expert in cosmetic science, Dr. Gabriella Baki. She’s an associate professor at the University of Toledo’s College of Pharmacy and Pharmaceutical Sciences and the Program Director of its groundbreaking Cosmeti...

On this episode of A SkinDepth Convo, we’re talking confidence, growth, and making 50 look fierce. Metaxia and Francine welcome the brilliant Kimyatta Albert, who’s celebrating her milestone birthday not just with a “50 and fabulous” party, but with an unwavering sense of purpose. Kimyatta, a renowned esthetician, mindset coach, and business mentor, dives into what it means to hit life’s big milestones with style and strength. She’ll reveal how to harness your inner resilience, radiate confiden...

Get ready to glow from head to toe! On this episode of A SkinDepth Convo, Metaxia and Francine tackle body confidence beyond your face. Skincare isn’t just about your face—we’re talking self-care rituals, head-to-toe skin love, and the hottest trends in 2025. Tune in for tips, innovations, and all the inspiration to feel confident in your skin!

On this episode of A SkinDepth Convo, Metaxia and Francine take you behind the scenes of the Purely Clinical Global Skin Affair Tour—sharing unforgettable moments, expert insights, and what’s in store for Purely Clinical 2.0! Get ready for the most anticipated skincare event of 2025, where professionals worldwide will dive into cutting-edge skin condition education and the latest breakthroughs in barrier-building science.

Can what you eat really make or break your skin? If you’re struggling with acne, a good skincare routine is key—but what’s on your plate might be just as important for achieving clear, healthy skin from the inside out! Metaxia and Francine are joined by nutritionist Maria Marlowe, who specializes in acne and is the author of "The Real Food Guide" and "Be Healthy Every Day." Listen now as Maria shares her expertise on the connection between our gut and skin, common acne-triggering mistakes, and h...

2024 has been a year of growth in the skincare and beauty industry. Lira Clinical has launched the latest technology in delivery with barrier protection, EXO-tech™, added a breakthrough refinement eye crème to the PRO Line, expanded the SMART PEELS™ collection, connected with new friends nationally and internationally, and now Lira Clinical is expanding their corporate office! Join Metaxia Dalikas and Francine Kagarakis to look at some of the best moments of 2024 and review some of the forecaste...

Expanding SMART PEELS™ When it comes to peels, the first thought that comes to mind is corrective skincare. Traditional peeling involved skin inflammation, longer recovery times, and only for specific skin types and conditions. We’ve come a long way from that. Metaxia and Francine get together again, exploring the latest advancements in skincare technology as Lira Clinical continues to innovate new peels for brighter, healthier, and younger-looking skin. Listen now and learn the science, innova...

Peel Appeal with Metaxia Dalikas & Francine Kagarakis In this episode of A SkinDepth Convo, we are peeling back the layers of clinical skincare. Peels are a major cornerstone in professional and clinical skincare, offering purely transformative results for different skin conditions. Listen now as Metaxia and Francine break down everything you need to know about peels and answer questions such as “Which peel is right for you or your clients?” “Why is it essential for skin health?” and “What make...