Episodes

Gray zones of VTE management! How to approach anticoagulation duration in unprovoked, provoked-irreversible, and provoked-reversible clots? When dose-reduced DOACs make sense for long-term secondary prevention? What truly constitutes DOAC failure? We also devle into how APLAS a critical do-not-miss diagnosis that changes management entirely. 🔹 Sponsor: Pain Management and Opioids Adaptive Learning Free Online Course by NEJM Group: https://cme-info.nejm.org/core-im/ 🔹 Transcript & Shownotes (2:...

We hope these stories resonate with anyone who has felt pulled between professional purpose and personal life, and remind you that you’re not alone in wanting both. 🔹 Sponsor: Oakstone CME Use the code "CORE30" for 30% off: https://www.coreimpodcast.com/MKSAP 🔹 Transcript and Shownotes (1:09) | How the Horn Award Opened the Door to Growth in Dr. Tyra Fainstad’s Career and Life (10:28) | How Dr. Carol Ward Created the Horn Award and Honored Mary Horn’s Legacy (14:16) | Dr. Hilit Mechaber’s Sto...

Antibiotic duration for bacteremia is something most of us learned by habit, not by trial data. In this episode, we walk through the BALANCE trial and use it as a lens to revisit how 1) host, 2) organism, and 3) source should guide treatment. When shorter really is enough, and when it isn’t? 🔹 Sponsor: Oakstone CME Use the code "CORE30" for 30% off: https://www.coreimpodcast.com/MKSAP 🔹 Transcript and Shownotes Timestamp (02:58) | Host, Organism, Source: The Core Framework Behind Duration (09:...

How quickly can triglycerides rise? At what threshold are patients at risk of pancreatitis or cardiovascular adverse outcomes? What do you have to rule out? How do you counsel on lifestyle changes? Which medications do you start with why and when? 🔹 Transcript and Shownotes (03:19) | Lipoprotein Lipase and Why Triglycerides Fluctuate Fast (05:27) | Triglycerides as a Cardiovascular Risk Marker (09:28) | Acute Management For Pancreatitis induced by Triglycerides (14:34) | Lifestyle Counseling...

Why is venous congestion not the same as volume overload? How can looking at IVC as well as doppler on the hepatic vein, portal vein, and/or intrarenal vein help? Can venous congestion explain someone's delirium? Or be at play in septic shock? What are the limitations of the VEXUS score? 🔹 Sponsor: Oakstone CME Use the code "CORE30" for 30% off: https://www.coreimpodcast.com/MKSAP 🔹Transcript and Shownotes (00:00) | Volume overload vs. Venous Congestion (05:49) | Venous Congestion and AKI, m...

SGLT-2i vs. GLP-1? vs Metformin? How do you balance the cost and coverage of first-line options like metformin, SGLT-2, and GLP-1s? How do you choose between SGLT-2 and GLP-1s for comorbidities like CAD or CKD? And how do you weigh their side effects and practical use? 🔹 Sponsor: Use the code "CORE30" for 30% off: https://www.coreimpodcast.com/MKSAP 🔹 Transcript and Show Notes Timestamps: (01:43) | Case 1: Managing Uncontrolled Diabetes in a 47-Year-Old Male (07:15) | Understanding Cost and In...

What really works when treating HRS? Vasoconstrictors like terlipressin vs. norepinephrine vs. midodrine: how do we decide which to use? Do you give albumin? When do you give Lasix or another diuretic? When is the better choice transplant, dialysis, or even palliative care? 🔹 Sponsor: Oakstone CME Use the code "CORE25" for 25% off: https://www.coreimpodcast.com/MKSAP 🔹 Transcript & Show Notes Timestamps: (00:12) | Introduction and Overview of Hepatorenal Treatment (03:38) | Vasoconstrictors F...

HRS-AKI vs. other causes of AKI in cirrhosis: What do serum or urine sodium clues, albumin challenges, and shifting diagnostic criteria actually reveal about getting the diagnosis right? 🔹 Sponsor: Oakstone CME Use the code "CORE25" for 25% off: https://www.coreimpodcast.com/MKSAP 🔹 Transcript & Show Notes Timestamps: (00:57) | Understanding the Pathophysiology of HRS (03:42) | How Portal Hypertension Traps the Kidneys (10:32) | Sorting the Differential of AKI in Cirrhosis Beyond HRS (18:28...

Who’s really at risk for fractures, and how should we be treating them? Most fragility fractures occur in patients without osteoporosis. Should we rethink who gets treated? And could just one or two IV infusions (spread years apart) of zoledronate prevent fractures for years? Have the concerns about bisphosphonates been overblown? Find out all the nuances on this episode of Beyond Journal Club, a series brought to you by Core IM in collaboration with NEJM Group. 🔹 Sponsor: Oakstone CME Use th...

Medications for orthostatic hypotension! When to initiate treatment, how to use them safely, and what to do when new issues arise during treatment. How do those change if someone has autonomic failure? What do you do when your patient has hypertension AND also has orthostatic hypotension? 🔹 Sponsor: Oakstone CME’ Use the code "CORE25" for 25% off: https://www.coreimpodcast.com/MKSAP 🔹 Transcript & Show Notes Timestamps (+/- 1-2 mins): (00:28) | Case Recap: Beyond Non-Pharm Strategies (03:07) ...

Learn specific, practical ways to counsel patients on non-pharmacologic interventions. What is our goal with OH treatment? Is it the blood pressure number that matters? How do we avoid missing neurogenic causes of orthostatic hypotension (OH)? 🔹 Sponsor: Oakstone CME’ Use the code "CORE30" for 30% off effective 11/1/25 through 1/31/26: https://www.coreimpodcast.com/MKSAP 🔹 Transcript & Show Notes Timestamps: (00:05) | Case Presentation: Urinary Retention → Lightheadedness (02:37) | Defining O...

Next time you’re squinting at a chest tube, feel confident you know exactly what to look for and why. Hear it explained in a way that really sticks! 🔹 Sponsor: Oakstone CME’s ACP MKSAP Audio Companion Use the code "CORE30" for 30% off effective 11/1/25 through 1/31/26: https://www.coreimpodcast.com/MKSAP 🔹 Transcript & Show Notes Timestamps: (02:50) | Xray vs. POCUS vs. CT for Pneumothorax Diagnosis (07:29) | Do All PTXs Need Chest Tubes? (11:55) | Explaining Pneumothorax to Patients (14:58...

How do you work up neutropenia? When is neutropenia benign? When do neutrophils recover? How can you diagnose neutropenic fever in the first 15 minutes and start antibiotics in the first 60 minutes? Do you always add MRSA coverages? Only Pseudomonas coverage? When do you add fungal coverage? 🔹 Sponsor: Oakstone CME’s ACP MKSAP Audio Companion Use the code "CORE30" for 30% off effective 11/1/25 through 1/31/26: https://www.coreimpodcast.com/MKSAP 🔹 Transcript & Show Notes Timestamps: (02:24) |...

Have a good laugh and reflect deeply with these three stories that hit the feels in different ways. If you'd love to hear more stories from Dr. Maria Rosasco, check out some of her other appearances on the podcast: July Stories and Handoffs & Contingency Planning. 🔹 Sponsor: Oakstone CME’s ACP MKSAP Audio Companion Use the code "CORE30" for 30% off effective 11/1/25 through 1/31/26: https://www.coreimpodcast.com/MKSAP 🔹 Transcript and Show Notes Timestamps: (01:04) | Story 1: Sharing a Perso...

What went wrong? What were the reasoning or contextual missteps that led us astray? 🔹 Sponsor: NEJM Fellowship Program, click here to learn more and/or apply! Due Aug 1, 2025 🔹 Transcript and Show Notes Timestamps: (00:02) | Case Presentation and Initial Diagnosis (02:47) | Tachycardia and Early Impressions (04:10) | Clinical Deterioration and New Clues (07:19) | Problem Representation and Reflection (21:45) | Lessons on Reasoning and Bias (26:55) | Final Takeaways and Action Steps Tags...

Imaging Pearls | (01:12) Deciding on Thoracentesis | (04:00) Light’s Criteria and Pseudoexudates | (07:00) Pleural Fluid Studies: pH and Cell Differential | (16:56) Diagnosing and Treating Parapneumonic Effusions | (23:32) Malignant Pleural Effusions: Diagnosis and Management | (30:39) 🔹 Sponsor: Oakstone CME’s ACP MKSAP Audio Companion Use the code "CORE30" for 30% off effective 11/1/25 through 1/31/26: https://www.coreimpodcast.com/MKSAP 🔹 Transcript and Show Notes Tags: Internal Medic...

Listen for some good laughs and relatable stories! In this episode, we share raw and real stories from July — from rapid responses to unexpected kindness — and reflect on the emotional weight of starting out in medicine. 🔹 Sponsor: NEJM Fellowship Program, click here to learn more and/or apply! Due Aug 1, 2025 🔹 Transcript and Show Notes Prior July Stories: July Stories 2.0 (2023) July Stories (2019) Timestamps: (00:32) | Dr. Ali Trainor's First Day as an Intern (03:00) | The Patient's Cri...

How much do beta blockers help after a heart attack, even when the heart’s pumping well? In this episode, we revisit the origins of beta blockers in post-MI care, examine how evidence evolved, and explore the REDUCE-AMI trial, which questions whether beta blockers are still needed for all. Listen to this latest episode of Beyond Journal Club, a collaboration between Core IM and NEJM Group, where we put research into context tracing the arc of evidence, dissecting the clinical question, and expl...

🔹 What is invasive fungal disease, and who is most at risk for developing invasive fungal disease? (~ 02:46) 🔹 What are the main classes of fungi? (~11:35) 🔹 What are the pros and cons of B-D Glucan and Galactomannan (~19:16) 🔹 How to increase the yield of blood cultures? How to interpret yeast growth in sputum/BAL and urine cultures? (~ 30:42) 🔹 How is invasive fungal disease treated? (~ 35:14) 📌 Sponsor: Oakstone CME’s ACP MKSAP Audio Companion Use the code "CORE30" for 30% off effective...

🔹What are clinically relevant limitations of an A1c vs. a CGM (1:40) 🔹What do the different parts of the ambulatory glucose profile tell you? (09:59) 🔹What are common pitfalls, medications, lifestyle patterns that are important to ask your patient about when seeing them for a visit to manage blood sugar? (15:19) 🔹 How can you titrate insulin based on when you see the hypoglycemia on the ambulatory glucose profile (20:00) 🔹 When there is too much hyperglycemia, how do you titrate insulin when...

🔹When is an U/S vs. CT vs. MRI helpful before consulting Interventional Radiology? 🔹What factors go into an IR pre-op evaluation? 🔹 When do drains go in, and when do they come out? 🔹 When a patient has trouble with a drain, what are things you can do before calling IR? 🔹 What does outpatient IR follow up entail, and what does a capping trial of PCN tubes entail? 📌 Sponsor: Oakstone CME’s ACP MKSAP Audio Companion Use the code "CORE30" for 30% off effective 11/1/25 through 1/31/26: https://...

🔹 High-yield reversible causes of constipation? (02:26) 🔹 Which type of fiber is more helpful? And is more hydration really better? And bulk-forming laxatives (9:03) 🔹 Osmotic vs Stimulant Laxatives (15:06) 🔹 Suppositories and enemas? (25:39) 🔹Best practices with opioid induced constipation (34:05) 📌 Sponsor: Freed is an AI scribe that listens and writes your note in < 30 seconds. Freed learns your style over time and is HIPAA compliant! Use the code CORE50 to get 50% off your first month ...

How good are we at preventing HIV? How do efficacy and effectiveness differ? We journey from oral pre-exposure prophylaxis (PrEP) to long-acting injectables, and then to the PURPOSE trials, which look at the use of long-acting lenacapavir as PrEP — a potential game-changer in the field of HIV. Listen to this latest episode of Beyond Journal Club, a collaboration between CoreIM and NEJM Group, where we put research into context, telling the story of how we arrived at the current standard of care...

What does Lipoprotein(a) tell us that a standard lipid panel doesn’t? Should we be testing everyone for it? Dive into the genetics, clinical implications, and evolving management strategies for Lp(a). Learn how to interpret results, counsel patients, and navigate topics with limited data like aspirin and PCSK9 inhibitors in treatment. 🔹 Sponsor: Freed is an AI scribe that listens and writes your note in < 30 seconds. Freed learns your style over time and is HIPAA compliant! Use the code CORE50...